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Forschungszentrum DZNE

@dzne@social.bund.de
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Das "Deutsche Zentrum für Neurodegenerative Erkrankungen" (DZNE) forscht zu Erkrankungen des Gehirns und Nervensystems, wie z. B. #Alzheimer, #Parkinson und #ALS. Toots in Deutsch und Englisch - D. Bayer (db), M. Neitzert (mn)

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163 Following
50 Posts
Joined November 16, 2022
Webseite:
https://www.dzne.de
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https://www.dzne.de/datenschutz
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https://www.dzne.de/impressum
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Forschungszentrum DZNE @dzne@social.bund.de
· 2mo ago

New paper out: Drawing a line: Differentiating mild from moderate dementia using the functional activities questionnaire.: Ersözlü, Ersin; Preis, Lukas; Aktuz, Aykut; et al.
The journal of prevention of Alzheimer's disease Vol. 13, no. 8, p. 100630 - http://dlvr.it/TTgVfh | Please share #dzne #papers

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Drawing a line: Differentiating mild from moderate dementia using the functional activities questionnaire. - DZNEPUB

Accurate differentiation between mild and moderate dementia is increasingly important, particularly as amyloid-targeting therapies are restricted to early disease stages. Functional impairment in instrumental activities of daily living is a hallmark of progression beyond mild dementia. The informant-based Functional Activities Questionnaire (FAQ) is widely used, but empirically validated cut-offs distinguishing mild from moderate dementia remain insufficiently defined.The optimal cut-off score w

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Forschungszentrum DZNE @dzne@social.bund.de
· 2mo ago

New paper out: Parkinson's disease genetics across diverse ancestries: an observational genetic study of causal and risk variants with translational implications: Lange, Lara M; Fang, Zih-Hua; Makarious, Mary B; et al.
The lancet Vol. 25, no. 8, p. 741 - 754 http://dlvr.it/TThMxr | Please share #dzne #papers

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Parkinson's disease genetics across diverse ancestries: an observational genetic study of causal and risk variants with translational implications - DZNEPUB

The genetic architecture of Parkinson's disease varies considerably across ancestries, yet most previous genetic studies have focused on individuals of European ancestry. We aimed to characterise the distribution of established Parkinson's disease causal variants, as well as risk-associated variants with clinical implications (ie, variants in genes involved in pathways targeted by ongoing clinical trials), across ancestrally diverse populations.We conducted a multi-ancestry, observational, cross

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Forschungszentrum DZNE @dzne@social.bund.de
· 4mo ago

New paper out: PinkyCaMP: an mScarlet-based calcium sensor with enhanced brightness, photostability and multiplexing capabilities.: Fink, Ryan; Imai, Shosei; Gockel, Nala Eileen; et al.
Nature methods Vol. 23, no. 5, p. 998 - 1010 http://dlvr.it/TSjDQj | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 4mo ago

New paper out: Arbeitsbedingungen von beruflich Pflegenden und deren Folgen, Teil 3: Schmidt, Sascha G.; Dichter, Martin; Hasselhorn, Hans M.
Lebenswelt Heim  http://dlvr.it/TShlrx | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 4mo ago

New paper out: New evidence on the clinical, genetic, and biochemical bases of GBA1-Parkinson's disease: prospects for treatment.: Menozzi, Elisa; Toffoli, Marco; Deleidi, Michela; et al.
The lancet Vol. 25, no. 6, p. 602 - 614 http://dlvr.it/TShKP5 | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 4mo ago

New paper out: IgLON5 autoimmune antibodies activate Tau via neuronal hyperactivity.: Askin, Bilge; Kilic, Cagla; Cordero Gómez, César; et al.
Science advances Vol. 12, no. 20, p. eaec2042 http://dlvr.it/TSh9fW | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 4mo ago

New paper out: Minor neuropsychological deficits and stage 2 of Alzheimer's disease.: Stark, Melina; Wagner, Michael; Kuhn, Elizabeth; et al.
Alzheimer's and dementia Vol. 22, no. 5, p. e71458 http://dlvr.it/TSg94Q | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 4mo ago

New paper out: Dataset: A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model. Kreye et al, v1: Kreye, Jakob; Reincke, Momsen; Kornau, Hans-Christian; et al.
  http://dlvr.it/TSZhj0 | Please share #dzne #papers

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Dataset: A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model. Kreye et al, v1 - DZNEPUB

The emergence of SARS-CoV-2 led to pandemic spread of coronavirus disease 2019 (COVID-19), manifesting with respiratory symptoms and multi-organ dysfunction. Detailed characterization of virus-neutralizing antibodies and target epitopes is needed to understand COVID-19 pathophysiology and guide immunization strategies. Among 598 human monoclonal antibodies (mAbs) from ten COVID-19 patients, we identified 40 strongly neutralizing mAbs. The most potent mAb CV07-209 neutralized authentic SARS-CoV-2

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Forschungszentrum DZNE @dzne@social.bund.de
· 4mo ago

New paper out: Dataset: Early IFN-a signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19, v2: Kraemer, Benjamin; Schultze, Joachim L.; Krämer, Benjamin; et al.
  http://dlvr.it/TSZDMX | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 5mo ago

New paper out: Dataset: Discovering unifying disease recovery dynamics in COVID-19. Frishberg et al., v1: Frishberg, Amit; Shen-Orr, Shai; Frishberg, Amit; et al.
  http://dlvr.it/TSYCGp | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 5mo ago

New paper out: Dataset: Axon initial segment dynamics during associative fear learning.: Benoit, Chloe; Ganea, Dan Alin; Paricio-Montesinos, Ricardo; et al.
  http://dlvr.it/TSRdPk | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 5mo ago

New paper out: Software: Axon initial segment dynamics during associative fear learning, v1: Benoit, Chloe; Ganea, Dan Alin; Paricio-Montesinos, Ricardo; et al.
  http://dlvr.it/TSRPds | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 2mo ago

New paper out: HTZ-1/H2A.Z expression sustains transcriptional programs that regulate Caenorhabditis elegans lifespan.: Xie, Beijia; Scifo, Enzo; Menegatou, Ioanna-Maria; et al.
Mechanisms of ageing and development Vol. 232, p. 112217 - http://dlvr.it/TTcYZD | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 2mo ago

New paper out: Early Alzheimer´s disease blood biomarkers are associated with a higher risk for postoperative long-term cognitive decline: Insights from the FINDERI study.: Hansen, Niels; Sadlonova, Monika; Esselmann, Hermann; et al.
Alzheimer's and dementia Vol. 22, no. 7, p. e71631 http://dlvr.it/TTj5tv | Please share #dzne #papers

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Early Alzheimer´s disease blood biomarkers are associated with a higher risk for postoperative long-term cognitive decline: Insights from the FINDERI study. - DZNEPUB

The study aim is to investigate whether blood biomarkers (BBMs) of Alzheimer's disease (AD) pathology are associated with postoperative cognitive dysfunction (POCD) after cardiac surgery.Cognitive performance was assessed before and 12 months postoperatively using the Montreal Cognitive Assessment (MoCA) and categorized into stages-minimal (1), notable (2), and substantial (3) decline-in the FIND DElirium RIsk factors (FINDERI) study of patients undergoing cardiac surgery. BBMs were measured pre

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Forschungszentrum DZNE @dzne@social.bund.de
· 5mo ago

New paper out: Dataset: Supplemental Material, Marchetti Giovanni and Gaia Tavosanis, Manuscript submitted to Current Biology, 2017, v3: Marchetti, Giovanni; Tavosanis, Gaia
  http://dlvr.it/TSXH3b | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 4mo ago

New paper out: DNA methylation signatures of bilateral hippocampal volume, asymmetry and atrophy: a cross-omics analysis in the general population.: Liu, Dan; Talevi, Valentina; Tavares, Juliana F; et al.
EBioMedicine Vol. 128, p. 106289 - http://dlvr.it/TShd6T | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 5mo ago

New paper out: Dataset: Multi-omic single-nucleus ATAC-seq + RNA-seq of nuclei from the post-mortem human primary motor cortex from patients with ALS, ALS-FTD, C9ORF72-ALS-FTD and neurologically unaffected controls, v1: Grozdanov, Veselin; Danzer, Karin
  http://dlvr.it/TSSLr3 | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 4mo ago

New paper out: Phenotypic spectrum of FGF14-related late-onset ataxia: predominant tremor and cognitive decline as key features of SCA27A.: Möller, Meret; Fienemann, André; Trinh, Joanne; et al.
Journal of neurology Vol. 273, no. 6, p. 309 http://dlvr.it/TSh1td | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 2mo ago

New paper out: Aquaporin-4 in Narcolepsy Type 1: Investigation of Perivascular Fluid Movement in Sleep Disorders.: Ranke, Jonas; Steinacker, Petra; Halbgebauer, Steffen; et al.
Annals of Clinical and Translational Neurology Vol. 13, no. 7, p. 1498 - 1502 http://dlvr.it/TTfNt5 | Please share #dzne #papers

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Aquaporin-4 in Narcolepsy Type 1: Investigation of Perivascular Fluid Movement in Sleep Disorders. - DZNEPUB

Narcolepsy type 1 (NT1) is caused by the loss of hypocretin-1 leading to excessive daytime sleepiness and cataplexy. Additionally, disrupted nighttime sleep has become an increasingly recognized feature of NT1. As the glymphatic fluid movement has been linked to sleep architecture, we investigated cerebrospinal fluid (CSF) Aquaporin-4 (AQP4) as potential biomarker for perivascular fluid exchange processes in 133 NT1 patients, 145 patients with other sleeping disorders, and 62 controls. NT1 patie

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Forschungszentrum DZNE @dzne@social.bund.de
· 4mo ago

New paper out: Benutzerhandbuch für die deutschsprachige QUALIDEM Version 2.0: Dichter, Martin; Ettema, Teake P.; Schwab, Christian; et al.
  http://dlvr.it/TSqjTG | Please share #dzne #papers

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Benutzerhandbuch für die deutschsprachige QUALIDEM Version 2.0 - DZNEPUB

Dichter, Martin; Ettema, Teake P.; Schwab, Christian; Meyer, Gabriele; Bartholomeyczik, Sabine; Halek, Margareta

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Forschungszentrum DZNE @dzne@social.bund.de
· 2mo ago

New paper out: Spatio-temporal gait signatures across prodromal and early Parkinson's disease in two independent cohorts.: Zatti, Cinzia; Hansen, Clint; Rizzardi, Andrea; et al.
Scientific reports Vol. 16, no. 1, p. 21897 http://dlvr.it/TTdPg5 | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 2mo ago

New paper out: Synaptophysin density underestimates synapse counts in the human brain - An anatomical study on synaptoporin protein expression.: Woelfle, Sarah; Schön, Michael; Pedro, Maria T; et al.
Neurobiology of disease Vol. 227, p. 107503 - http://dlvr.it/TTbzk7 | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 2mo ago

New paper out: Miro1 mutations disrupt cellular calcium homeostasis via dysregulation of mitochondria-ER-contact-sites, rendering iPSC-derived neurons more susceptible to lipid peroxidation.: Bartalis, Anna E; Genschmar, Jack; Fitzgerald, Julia C; et al.
Neurobiology of disease Vol. 227, p. 107492 - http://dlvr.it/TTc3Lf | Please share #dzne #papers

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Miro1 mutations disrupt cellular calcium homeostasis via dysregulation of mitochondria-ER-contact-sites, rendering iPSC-derived neurons more susceptible to lipid peroxidation. - DZNEPUB

The pathogenesis of Parkinson's disease is multifactorial, but disruption of calcium and iron is a common feature. The mitochondrial Rho GTPase Miro1 is a component of the mitochondrial-endoplasmic reticulum contact sites and a key regulator of calcium homeostasis. Heterozygous variants in the Miro1-encoding gene RHOT1 were identified in Parkinson's disease patients. Neurons harboring Parkinson's disease-associated variants show defects in mitochondrial calcium regulation and mitochondria-ER con

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Forschungszentrum DZNE @dzne@social.bund.de
· 4mo ago

New paper out: Dataset: PNN unit analysis, v1: Dityatev, Alexander; Dityatev, Alexander
  http://dlvr.it/TSZMhD | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 2mo ago

New paper out: Reply to the Letter to the Editor: Blind spots in radiology leadership regarding human resources and organization management in the era of artificial intelligence.: Wichtmann, Barbara D; Paech, Daniel; Pianykh, Oleg S; et al.
European radiology Vol. 36, no. 8, p. 6842 - 6844 http://dlvr.it/TTcB10 | Please share #dzne #papers

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Reply to the Letter to the Editor: Blind spots in radiology leadership regarding human resources and organization management in the era of artificial intelligence. - DZNEPUB

Wichtmann, Barbara D; Paech, Daniel; Pianykh, Oleg S; Huang, Susie Y; Seltzer, Steven E; Brink, James; Fennessy, Fiona M

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Forschungszentrum DZNE @dzne@social.bund.de
· 2mo ago

New paper out: Prevalence of delirium in German nursing homes: A cross-sectional study.: Houdelet-Oertel, Alexandre; Dörner, Jonas; Walter, Roberto; et al.
BMC geriatrics Vol. 26, no. 1, p. 938 http://dlvr.it/TTgH9N | Please share #dzne #papers

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Prevalence of delirium in German nursing homes: A cross-sectional study. - DZNEPUB

Delirium is a common geriatric syndrome. However, there is a lack of primary data regarding the prevalence of delirium in German nursing homes. The aim of this study was to assess the prevalence of delirium and its motor subtypes, and to identify factors associated with the prevalence of delirium among residents of German nursing homes.This multicenter cross-sectional study was conducted in German nursing homes. Trained nurses collected data over a two-week period in April 2024. The participants

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Forschungszentrum DZNE @dzne@social.bund.de
· 2mo ago

New paper out: Co-regulation of HIV control and cytomegalovirus pp65-specific IL-1β and TNF-α responses by genetic variants in the MHC region.: Ruijten, Suzanne D E; Dos Santos, Jéssica C; Rios-Vazquez, Victoria; et al.
PLoS pathogens Vol. 22, no. 7, p. e1014355 - http://dlvr.it/TThtlk | Please share #dzne #papers

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Co-regulation of HIV control and cytomegalovirus pp65-specific IL-1β and TNF-α responses by genetic variants in the MHC region. - DZNEPUB

The spontaneous control of HIV infection in the absence of antiretroviral therapy, termed HIV control, is associated with genetic variation in the Major Histocompatibility Complex (MHC) locus. These variants are known to influence the immune response to HIV itself. However, people living with HIV are often co-infected with other pathogens that can also elicit immune responses, which might also be regulated by these variants. Here, we assessed whether genetic variants associated with HIV control

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Forschungszentrum DZNE @dzne@social.bund.de
· 4mo ago

New paper out: Potential proteomic biomarkers for monitoring clinical studies in Duchenne/Becker muscular dystrophy.: Dowling, Paul; Bouragba, Dounia; Negroni, Elisa; et al.
Expert review of proteomics Vol. 23, no. 4-5, p. 109 - 120 http://dlvr.it/TSgP5P | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 5mo ago

New paper out: Software: BART: Toolbox for Computational Magnetic Resonance Imaging, v1.0.00: Blumenthal, Moritz; Schaten, Philip; Mackner, Daniel; et al.
  http://dlvr.it/TSS3N6 | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 4mo ago

New paper out: Dataset: Chimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells. Reincke et al, v1: Reincke, Momsen; Von Wardenburg, Niels; Homeyer, Marie; et al.
  http://dlvr.it/TSYfWd | Please share #dzne #papers

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Dataset: Chimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells. Reincke et al, v1 - DZNEPUB

Here we provide raw data and graphpad prism analysis on the animal studies, western blot, histology and ELISpot published in 'Chimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells.' Reincke et al Reincke, Momsen; Von Wardenburg, Niels; Homeyer, Marie; Neurologie, Charite Universitatsmedizin Berlin Klinik fur Neurologie mit Experimenteller; Erkrankungen, Deutsches Zentrum fur Neurodegenerative

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Forschungszentrum DZNE @dzne@social.bund.de
· 5mo ago

New paper out: Dataset: Main Figures Tabular Data - The mitochondrial unfolded protein response disrupts neuronal–glial communication and promotes senescence in human microglia (v3): Pérez-Jiménez, María José; Raji, Hariam; Bertoli, Federico; et al.
  http://dlvr.it/TSSgWg | Please share #dzne #papers

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Dataset: Main Figures Tabular Data - The mitochondrial unfolded protein response disrupts neuronal–glial communication and promotes senescence in human microglia (v3) - DZNEPUB

This archive contains the source numerical data underlying all figures of the manuscript:Title: The mitochondrial unfolded protein response disrupts neuronal–glial communication and promotes senescence in human microgliaAuthors: Maria Jose Perez J., Alicia Lam, Christin Weissleder, Federico Bertoli, Hariam Raji, Mariella Bosch, Ivan Nemazanyy, Stefanie Kalb, Mohammed Kehili, Insa Hirschberg, Dario Brunetti, Indra Heckenbach, Morten Scheibye-Knudsen, and Michela DeleidiDate: October 2025Correspon

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Forschungszentrum DZNE @dzne@social.bund.de
· 2mo ago

New paper out: Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points.: Grobe-Einsler, Marcus; Maas, Vivian; Amin, Arian Taheri; et al.
Annals of Clinical and Translational Neurology Vol. 13, no. 7, p. 1370 - 1378 http://dlvr.it/TTfHd8 | Please share #dzne #papers

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Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points. - DZNEPUB

Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician-reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short-term fluctuations, limiting its sensitivity in trials. To overcome this, we employed SARAhome, a video-based, self-administered tool for high-frequency, remote ataxia assessment.We assessed feasibility and validity of SARAhome in 65 S

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Forschungszentrum DZNE @dzne@social.bund.de
· 2mo ago

New paper out: Habenula volume alterations in adults born very preterm.: Stüwe, Theresa; Maurer, Angelika; Daamen, Marcel; et al.
Scientific reports Vol. 16, no. 1, p. 22071 http://dlvr.it/TThyVx | Please share #dzne #papers

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Habenula volume alterations in adults born very preterm. - DZNEPUB

Preterm birth is a major risk factor for childhood psychopathology, including higher rates of anxiety and avoidant personality traits persisting into adulthood. While extensive research has documented volumetric reductions in various brain structures associated with emotional processing in preterm individuals, the habenula, a key component in affective and reward processing, has not yet been studied in this context. This study examines whether adults born very preterm show alterations in the hab

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Forschungszentrum DZNE @dzne@social.bund.de
· 5mo ago

New paper out: Dataset: Supplementary Figures Tabular Data - The mitochondrial unfolded protein response disrupts neuronal–glial communication and promotes senescence in human microglia (v2): Pérez-Jiménez, María José; Bertoli, Federico; Weissleder, Christin; et al.
  http://dlvr.it/TSTKSk | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 2mo ago

New paper out: Neuroimaging Correlates of Post-Stroke Pain After Ischemic Stroke: Secondary Analysis of the INSPiRE-TMS Trial.: Stegemann, Alina; Rios, Ana Sofia; Khalil, Ahmed; et al.
Human brain mapping Vol. 47, no. 10, p. e70602 http://dlvr.it/TTgBGM | Please share #dzne #papers

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Neuroimaging Correlates of Post-Stroke Pain After Ischemic Stroke: Secondary Analysis of the INSPiRE-TMS Trial. - DZNEPUB

Post-stroke pain (PSP) affects nearly half of stroke survivors, severely compromising quality of life. The causes of PSP remain underexplored, although there is likely a complex interplay of lesion effects, psychological factors, and mobility that play a role in its development. The aim of the study was to investigate clinical characteristics associated with PSP, as well as structural and functional correlates of PSP using lesion symptom (LSM) and network mapping (LNM). We analyzed data from the

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Forschungszentrum DZNE @dzne@social.bund.de
· 4mo ago

New paper out: The In Vivo Microstructural Profile of Human Hippocampal Subfield CA1 and Its Relation to Memory Performance.: Hayek, Dayana; Höpker-Fernandes, Joseph; Vockert, Niklas; et al.
Human brain mapping Vol. 47, no. 7, p. e70542 http://dlvr.it/TShtQD | Please share #dzne #papers

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The In Vivo Microstructural Profile of Human Hippocampal Subfield CA1 and Its Relation to Memory Performance. - DZNEPUB

The hippocampal CA1 subregion supports learning, memory formation, and spatial navigation. Although its three-layered architecture has been described in ex vivo investigations, the in vivo microstructural profile of CA1 and its relation to individual variations in memory performance remain poorly characterized. In this study, we used ultra-high field structural MRI at 7 Tesla to investigate the depth-dependent myelination patterns (measured by quantitative T1) of CA1 in younger adults, their rel

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Forschungszentrum DZNE @dzne@social.bund.de
· 4mo ago

New paper out: APTw CEST MRI in therapy-naive IDH-wildtype glioblastoma: insights into tumor heterogeneity and molecular subtypes.: Zeyen, Thomas; Decker, Andreas; Krause, Inga; et al.
Journal of neuro-oncology Vol. 178, no. 1, p. 9 http://dlvr.it/TSgclX | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 2mo ago

New paper out: Evidence-based care pathways for people with dementia and neurodegenerative disorders in Europe: a systematic review of models, integration of digital technologies, and quality indicators.: Cardona, Maria Isabel; Gakoudis, Parthena Nena; Macijauskienė, Jūratė; et al.
Frontiers in medicine Vol. 13, p. 1774318 http://dlvr.it/TTjSV9 | Please share #dzne #papers

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Evidence-based care pathways for people with dementia and neurodegenerative disorders in Europe: a systematic review of models, integration of digital technologies, and quality indicators. - DZNEPUB

Dementia and other neurodegenerative disorders place growing pressure on European health systems, yet evidence on how care pathways are structured, implemented, and evaluated remains fragmented. This systematic review synthesizes European evidence on dementia and neurodegenerative care pathways and develops an evidence-informed conceptual synthesis capturing core functions, domains of care delivery, and cross-cutting implementation principles. The review followed PRISMA 2020 guidelines and was r

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Forschungszentrum DZNE @dzne@social.bund.de
· 5mo ago

New paper out: Dataset: Data from: A human iPSC model of tauopathies engineered for 4R tau isoform expression endogenously develops late-stage neuronal tau pathology: Dannert, Angelika; Schulz, Nathalie; Klimmt, Julien; et al.
  http://dlvr.it/TSXVgR | Please share #dzne #papers

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Dataset: Data from: A human iPSC model of tauopathies engineered for 4R tau isoform expression endogenously develops late-stage neuronal tau pathology - DZNEPUB

Tauopathies, such as Alzheimer’s disease and Frontotemporal Dementia, are common neurodegenerative diseases characterized by misfolding, hyperphosphorylation, and aggregation of Tau. Molecular mechanisms underlying Tauopathies are still poorly understood, in part due to a lack of human models endogenously developing major disease hallmarks. Adult Tau isoform expression contributes to Tau pathogenesis but is challenging to replicate in human stem-cell-derived systems, which impedes the formation

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Forschungszentrum DZNE @dzne@social.bund.de
· 4mo ago

New paper out: Dataset: Data and statistical analysis for research article on Deficiency in MT5-MMP Supports Branching of Human iPSCs-Derived Neurons and Reduces Expression of GLAST/S100 in iPSCs-Derived Astrocytes published in Cells by Arnst et al. (2021), v1: Dityatev, Alexander
  http://dlvr.it/TSZ4R2 | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 5mo ago

New paper out: Dataset: Validity and value of metabolic connectivity in mouse models of β-amyloid and tauopathy, v2: Ruch, Francois; Ruch, Francois
  http://dlvr.it/TSYR55 | Please share #dzne #papers

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Dataset: Validity and value of metabolic connectivity in mouse models of β-amyloid and tauopathy, v2 - DZNEPUB

The goal of the current work was to analyze and validate metabolic regional network alterations in three different AD mouse models (β-amyloid and tau) by use of 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography (FDG-PET) imaging. We compared the results of FDG-µPET MC with conventional VOI-based analysis and behavioral assessment in the Morris water maze (MWM). MC proved to be an accurate and robust indicator of functional connectivity loss in AD mouse models when sample sizes ≥12 are

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Forschungszentrum DZNE @dzne@social.bund.de
· 5mo ago

New paper out: 3D print file for a replacement of Tokaihit magnetic lid for chamber slides: Fu, Yangting
  http://dlvr.it/TSSCV0 | Please share #dzne #papers

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Forschungszentrum DZNE @dzne@social.bund.de
· 2mo ago

New paper out: Evidence for early, clinically silent medial temporal lobe inflammation after CAR-T cell therapy.: Dubai, Marwa Al; Rebello, Mahima Verginia; Neumann, Katja; et al.
European journal of cancer Vol. 244, p. 116925 - http://dlvr.it/TTh9Br | Please share #dzne #papers

dlvr.it

Evidence for early, clinically silent medial temporal lobe inflammation after CAR-T cell therapy. - DZNEPUB

Immune effector cell-associated neurotoxicity syndrome (ICANS) is the most frequent neurological complication following chimeric antigen receptor (CAR)-T cell therapy. Long-term cognitive effects remain controversial, even in the absence of clinical neurotoxicity. CAR-T cell-associated neurotoxicity often involves the medial temporal lobe (MTL), yet conventional structural magnetic resonance imaging (MRI) frequently remains normal. There is a need for markers of subclinical neurotoxicity that ma

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Forschungszentrum DZNE @dzne@social.bund.de
· 2mo ago

New paper out: Variational sparse Gaussian-process method for detecting spatially variable genes and cellular interactions in spatial transcriptomics.: Wang, Zhicong; Li, Jing; Xie, Liqing; et al.
Briefings in bioinformatics Vol. 27, no. 4, p. bbag371 http://dlvr.it/TTdVpL | Please share #dzne #papers

dlvr.it

Variational sparse Gaussian-process method for detecting spatially variable genes and cellular interactions in spatial transcriptomics. - DZNEPUB

Advanced spatially resolved transcriptomic (SRT) technologies preserve the spatial context of gene expression within tissues, enabling the study of context-dependent transcriptional regulation. Here, we propose a variational inference-assisted sparse Gaussian-process (VISGP) framework for identifying spatially variable genes (SVGs) and inferring spatially dependent cellular interactions from SRT data. VISGP combines sparse Gaussian-process approximations with variational inference via inducing v

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Forschungszentrum DZNE @dzne@social.bund.de
· 2mo ago

New paper out: Value of MRI Outcomes for Preventive and Early-Stage Trials in Spinocerebellar Ataxias 1 and 3.: Rezende, Thiago J R; Petit, Emilien; Park, Young Woo; et al.
Annals of Clinical and Translational Neurology Vol. 13, no. 7, p. 1452 - 1466 http://dlvr.it/TTfcfs | Please share #dzne #papers

dlvr.it

Value of MRI Outcomes for Preventive and Early-Stage Trials in Spinocerebellar Ataxias 1 and 3. - DZNEPUB

To examine the value of MRI outcomes as endpoints for preventive and early-stage trials of two polyglutamine spinocerebellar ataxias (SCAs).A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene-negative controls) was scanned at 3T up to 6 times (median follow-up 3 years) in the READISCA study. Structural, microstructural, and neurochemical outcomes were assessed for sensitivity to change. Associations bet

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Forschungszentrum DZNE @dzne@social.bund.de
· 2mo ago

New paper out: Anti-NMDAR encephalitis impairs intrinsic hippocampal dynamics through neuronal hypercoupling, hub dominance, and aberrant ensembles.: Rahmati, Vahid; Graf, Jürgen; Ceanga, Mihai; et al.
Molecular psychiatry Vol. 31, no. 8, p. 4550 - 4562 http://dlvr.it/TTh47f | Please share #dzne #papers

dlvr.it

Anti-NMDAR encephalitis impairs intrinsic hippocampal dynamics through neuronal hypercoupling, hub dominance, and aberrant ensembles. - DZNEPUB

Autoimmune anti-NMDA-receptor encephalitis is characterized by autoantibody-induced NMDA receptor hypofunction leading to severe neuropsychiatric symptoms including psychosis, hallucinations, memory dysfunction and seizures. However, it remains enigmatic what changes in intrinsic network organization at the multi-neuronal level, serving as the neural substrate of brain function, underlie disease symptomology. Using a mouse model with passive-transfer of patient's monoclonal anti-GluN1-autoantibo

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Forschungszentrum DZNE @dzne@social.bund.de
· 5mo ago

New paper out: Dataset: Single-nucleus RNA-seq of human post-mortem primary motor cortex (M1) nuclei from ALS-FTD patients, NeuN+ (neuronal) and sorted for TDP-43 low vs. high signal, v1: Grozdanov, Veselin; Danzer, Karin
  http://dlvr.it/TSSxsf | Please share #dzne #papers

dlvr.it

Dataset: Single-nucleus RNA-seq of human post-mortem primary motor cortex (M1) nuclei from ALS-FTD patients, NeuN+ (neuronal) and sorted for TDP-43 low vs. high signal, v1 - DZNEPUB

This dataset comprises single-nucleus transcriptomic (RNA-seq) data from nuclei purified from the post-mortem human primary motor cortex (M1) from patients with ALS-FTD, after sorting for TDP-43 nuclear signal (NeuN+, TDP-43 low vs. high). Detailed methods and study description in the accompanying publication (tba). Grozdanov, Veselin; Danzer, Karin

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Forschungszentrum DZNE @dzne@social.bund.de
· 5mo ago

New paper out: Dataset: RNA Selectively Modulates Activity of Virulent Amyloid PSMα3 and Host Defense LL-37 via Phase Separation and Aggregation Dynamics, v3: Rayan, Bader; Barnea, Eilon; Indig, Rinat; et al.
  http://dlvr.it/TSSpsr | Please share #dzne #papers

dlvr.it

Dataset: RNA Selectively Modulates Activity of Virulent Amyloid PSMα3 and Host Defense LL-37 via Phase Separation and Aggregation Dynamics, v3 - DZNEPUB

Amyloids, classically linked to neurodegenerative diseases, also play critical roles in infection and immunity. Phenol-soluble modulins (PSMs) from Staphylococcus aureus are virulent amyloids that contribute to cytotoxicity, immune modulation, and biofilm stability. PSMα3 forms cross-α amyloid fibrils and shares sequence and structural features with LL-37, a human host-defense peptide that assembles into α-helical structures. Here, we uncover RNA as a potent, context-dependent modulator of their

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Forschungszentrum DZNE @dzne@social.bund.de
· 2mo ago

New paper out: Survival estimates and their predictors in genetic frontotemporal dementia: an international, retrospective, cohort study: Bouzigues, Arabella; Grassi, Mario; Cantoni, Valentina; et al.
The lancet Vol. 25, no. 8, p. 731 - 740 http://dlvr.it/TTdkMK | Please share #dzne #papers

dlvr.it

Survival estimates and their predictors in genetic frontotemporal dementia: an international, retrospective, cohort study - DZNEPUB

What drives the heterogeneity of survival estimates in genetic frontotemporal dementia is unknown. We sought to understand the natural history and predictors of disease trajectory, which are crucial not only for effective care but also for the design of therapeutic clinical trials and efficacy evaluation.In this international, cohort study, we used the Kaplan-Meier method to retrospectively assess survival estimates in patients enrolled in the GENFI cohort, which included 32 research sites locat

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Forschungszentrum DZNE @dzne@social.bund.de
· 5mo ago

New paper out: Data from: Microglial motility is modulated by neuronal activity and correlates with dendritic spine plasticity in the hippocampus of awake mice: Nebeling, Felix; Fuhrmann, Martin; Diseases, German Center for Neurodegenerative
  http://dlvr.it/TSXkYX | Please share #dzne #papers

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