Experiments wiith mice found that extreme calorie restriction (30% fewer calories) was associated with fewer mutations. The change in mutation rate differed between tissues; the reduction was greater in liver cells than in kidney or brain cells. In liver and kidney cells, the reduction was greatest in the least active parts of the genome. Summary: https://scitechdaily.com/eating-30-less-food-has-an-unexpected-effect-on-dna-study-finds/ Original paper (not open access): https://www.cell.com/cell/abstract/S0092-8674(26)00940-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867426009402%3Fshowall%3Dtrue #Science #Mutations #CalorieRestriction #Fasting