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Guillaume Gaullier

Guillawme@fediscience.org

<p>Researcher from 🇫🇷 doing <a href="https://fediscience.org/tags/cryoEM" class="mention hashtag" rel="tag">#<span>cryoEM</span></a> ❄️🔬 at Uppsala University 🇸🇪<br />Working on cyanobacterial carboxysomes 🦠, still interested in nucleosome 🧬🙃🧬<br />Mostly science posts and chatter in English, occasionally in French.</p><p>Born at 356 ppm.</p><p><a href="https://fediscience.org/tags/StructuralBiology" class="mention hashtag" rel="tag">#<span>StructuralBiology</span></a> <a href="https://fediscience.org/tags/Biochemistry" class="mention hashtag" rel="tag">#<span>Biochemistry</span></a> <a href="https://fediscience.org/tags/Science" class="mention hashtag" rel="tag">#<span>Science</span></a> <a href="https://fediscience.org/tags/AcademicChatter" class="mention hashtag" rel="tag">#<span>AcademicC

Posts

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    So, I still have this little Intel Nuc that I used to test Guix System during Christmas break 2024 (thread here: https://fediscience.org/@Guillawme/113611195137420871 ). I ended this experiment, but will probably use Guix again one way or another, sometime. At the moment there is a Debian 13 system on this computer. Quite easy to set up, which saved me mental bandwidth to learn other things with it. I managed to set up remote decryption of the luks partition following this tutorial: https://www...

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    Found a second-hand Intel-NUC from 2015 with decent specs, barely used. So I jumped on this opportunity to test #Guix and #GuixSystem! (Tried before in a VM, it works but isn&#39;t as exciting. And not ready to change OS on the laptop I use daily.) Poor little computer broke a sweat upon `guix pull` (from 1.4.0 to current), and now again with `guix system image` (generating an installation iso). I will try to `guix pull` frequently so each is a lighter operation. Very excited to try `guix hom...

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    Some questions for people into #cryoEM and #biochemistry All pKa values vary with temperature. This is especially apparent with Tris buffer: change of ~ +0.5 pH unit going from room temp to 4°C. Proton transfers in acid/base equilibria are very fast. Are they faster than vitrification? In other words, does a change of pKa (due to a rapid drop in temperature) of the buffer compound have the time to change the pH of the solution before it is fully vitrified? There are pH-sensitive fluorophores...

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    RE: https://wikis.world/@quarknova/116262006249339183 This is great news! I was in fact just coming to the realization that Wikipedia should be listed in my human.json file, so this resolution comes just at the right time.

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    RE: https://scholar.social/@khinsen/116249052896745512 This is an interesting experiment: bring back the old webring/blogroll concept based on trust between people, to help spot websites written by people in an ever deeper sea of generative AI content on the web. I just added it to my site (linked on my profile), and started building a list of the few sites I read regularly that are unambiguously crafted by humans. Happy to list other people&amp;#39;s websites too, so long as they are written...

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    #AlphaFoldDB now has binary protein complexes! https://www.ebi.ac.uk/about/news/technology-and-innovation/first-complexes-alphafold-database/ #AlphaFold #AlphaFold2 #StructuralBiology