Gain-of-function (GOF) research. It's back in the news, and I've got indirect experience in this. It is part of the "lab leak" hypothesis for the origin of COVID. There are some really key takeaways, but nobody's discussing those. I will. But first, what is Gain-of-Function research and why should we do it? Gain-of-Function research is where you take an infective disease causing agent and deliberately try to make it resistant to treatments. Why would you do this? [Thread]